Rob Riggle, Rob Lowe, Michael Rowe, Peyton Manning, Pete Davidson, Joel Gallen, Frank Sebastiano, Emmy Blotnick, Josh Comers, Michael Ferrucci, Ray James, Mike Lawrence, George Reinblatt, Sarah Tiana, Kevin Schini, Jesse Joyce, Hugh Fink, Jarrett Grode, Tony Hinchcliffe, Dan St. Germain, David Feldman, Pete Schultz, Guy Nicolucci, Sidney Karger

Comedy Central Roast of Rob Lowe is a TV special starring Rob Lowe, Peyton Manning, and Rob Riggle. It's Rob Lowe's turn to step in to the celebrity hot seat for the latest installment of The Comedy Central Roast.